Luscomb (Florence) is born in Lowell.

Raised in Boston, Florence Luscomb becomes one of the first women to graduate with a degree in architecture from the Massachusetts Institute of Technology in 1909, forms a two-woman firm in Watertown, and lives for a time at 17 Yarmouth Street. She serves as executive secretary of the Boston Equal Suffrage Association for Good Government, narrowly loses a race for Boston City Council in 1922, and is an unsuccessful Progressive Party candidate for U.S. House of Representatives in 1936 and 1950 and governor in 1952. Luscomb continues her activism in movements for peace, factory safety, civil rights, prison reform and against the Vietnam War. She dies in Watertown on October 27, 1985.