Boylston (Zabdiel) is born in Brookline.

The son of a doctor, Zabdiel Boylston grows up in Brookline (then Muddy River), studies medicine and becomes a doctor in Boston, maintaining an office at Dock Square. At the urging of Cotton Mather, he introduces inoculation against smallpox in Boston in 1721.* Boylston continues to practice medicine until 1753. He dies in Brookline on March 1, 1766.